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Descriptor English: Vaccines, DNA
Descriptor Spanish: Vacunas de ADN
Descriptor vacunas de ADN
Entry term(s) vacuna de ADN
vacuna de ADN desnudo
vacuna de ADN recombinante
vacunas de ADN desnudo
vacunas de ADN recombinante
vacunas de DNA
Scope note: Vectores de ADN recombinante que codifican antígenos y se administran para la prevención o el tratamiento de enfermedades. Las células anfitrionas toman el ADN, expresan al antígeno y lo presentan al sistema inmunitario de forma similar a lo que ocurriría durante una infección natural. Esto induce una respuesta inmunitaria, de tipo humoral y celular, contra los antígenos codificados. Al vector se lo denomina "ADN desnudo" ya que no son necesarias formulaciones complejas o agentes para suministrarlo; el plásmido se inyecta con solución salina u otros tampones.
Descriptor Portuguese: Vacinas de DNA
Descriptor French: Vaccins à ADN
Entry term(s): DNA Vaccine
DNA Vaccine, Naked
DNA Vaccine, Recombinant
DNA Vaccines
DNA Vaccines, Naked
DNA Vaccines, Recombinant
Naked DNA Vaccine
Naked DNA Vaccines
Recombinant DNA Vaccine
Recombinant DNA Vaccines
Vaccine, DNA
Vaccine, Naked DNA
Vaccine, Recombinant DNA
Vaccines, Naked DNA
Vaccines, Recombinant DNA
Tree number(s): D12.776.828.868.228.250
D20.215.894.865.450.250
D23.050.865.450.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019444
Scope note: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
MI microbiology
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
VI virology
Previous Indexing: Vaccines, Synthetic (1986-1996)
DeCS ID: 33063
Unique ID: D019444
NLM Classification: QW 805
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2020/05/27
Vaccines, DNA - Preferred
Concept UI M0028927
Scope note Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Preferred term Vaccines, DNA
Entry term(s) DNA Vaccine
DNA Vaccine, Naked
DNA Vaccine, Recombinant
DNA Vaccines
DNA Vaccines, Naked
DNA Vaccines, Recombinant
Naked DNA Vaccine
Naked DNA Vaccines
Recombinant DNA Vaccine
Recombinant DNA Vaccines
Vaccine, DNA
Vaccine, Naked DNA
Vaccine, Recombinant DNA
Vaccines, Naked DNA
Vaccines, Recombinant DNA



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